Colorado vs ASU Prediction, Odds, Spread and Over/Under for College Football Week 6

Glory Colorado has your odds, spread, over/under and predictions for Week 6's Colorado vs ASU matchup from Tempe, Arizona Mandatory Credit: Ron Chenoy-USA TODAY Sports
Glory Colorado has your odds, spread, over/under and predictions for Week 6's Colorado vs ASU matchup from Tempe, Arizona Mandatory Credit: Ron Chenoy-USA TODAY Sports /

Week 6’s Colorado vs ASU matchup from Tempe, Arizona is a massive chance for Coach Prime and his Buffs to bounce back following two losses; a spirited near-comeback against USC and a 42-6 blowout at the hands of Oregon. At 3-2, CU can surpass its preseason over/under win projection if they can defeat the Sun Devils.

At 1-4, defeating Arizona State isn’t a difficult task; or at least hasn’t been for Fresno State, who blanked the Sun Devils on the road in Week 2, Oklahoma State, USC, and even Cal.

ASU has used three quarterbacks thus far in 2023, with Trenton Bourguet being the likely starter against Colorado on October 7. Of every quarterback they’ve used, though, only injured freshman Jaden Rashada has a positive touchdown-interception ratio. What’s saving Arizona State this season is a defense in the top half of the country, though against Shedeur Sanders and Co., they still may be over their heads.

Can ASU pull off the upset at home in the third game of the season Colorado as the betting favorite?

Colorado vs ASU Odds, Spread, and Total

The point spread for Week 4 has Colorado as a -4.5 point favorite. Colorado is a -200 favorite on the moneyline, while ASU is a +165 underdog. The over/under is set at 59.5, meaning that the oddsmakers are expecting a high-scoring affair. All lines are courtesy of BetMGM and are subject to change.

Colorado vs ASU How to Watch

Date: October 7, 2023
Game Time: 4:30 pm Mountain Time
Venue: Mountain America Stadium in Tempe, Arizona
How to Watch: Pac-12 Network, which is available on FuboTV.
Colorado Record: 3-2
ASU Record: 1-3

Colorado vs ASU Key Players to Watch


Omarion Miller: Can freshman Omarion Miller replicate a seven-reception, one-touchdown, 196-yard breakout debut against USC? It’s not likely, but with Sanders throwing him the ball and Travis Hunter missing another week due to injury, the question needs to be asked.

Expect Miller to remain a notable target in Colorado’s offense, even if he doesn’t put up video game numbers again.

Cormani McClain: Things have changed rapidly for Cormani McClain since the press conference in which Coach Prime called out the cornerback for not doing enough for his teammates to see the field for the Buffs.

A heroic outing against USC in Week 5 has squashed any transfer portal rumors — and with Hunter’s continued absence, McClain can stake a claim to a starter’s load of snaps against Arizona State.


Cameron Skattebo: With ASU’s quarterback situation fluid, Cameron Skattebo has been getting a starter’s load worth of carries the past two weeks in losses to Cal and USC. Against the latter, he had a five-plus yards per carry showing in a loss to the Trojans that was closer than the scoreboard indicated.

Against Cal, though, Skattebo struggled mightily. Which Skattebo shows up against the Buffs could determine how close this game is going to be.

Elijah Badger: Despite the quarterback questions, Elijah Badger has emerged as the top receiving threat for the Sun Devils; with the past two games against Cal and USC in particular fueling that narrative.

Stopping Badger puts the pressure on an unproven receiving corps. Get that done, and ASU is hardly a challenge offensively.

Colorado vs ASU Prediction and Pick

The difference under center between these two teams will be blatantly obvious on October 7, and Buffs bettors will be happy to how well-prepared their guy is considering both teams are implementing a new offensive system, but ASU’s QB has been in Tempe for four years.

The newcomer Sanders will outduel Bourguet in a big way en route to another Buffaloes cover.

Prediction: Colorado -4.5